I’ve built a Mac (Intel) binary of DesMuME, from the latest SVN code, with a patch to enable masscat’s GDB stub. With it you can load a homebrew rom, connect to DesMuME with the copy of GDB that’s provided with devkitARM, and start debugging your homebrew code while it’s running in the emulator. For more details check out this post on the official forums.
The binary can be found here, and the modified parts of the source code can be downloaded here. Read More...